Reference · GLP-1 / GIP
Semaglutide
Semaglutide is a synthetic 31-residue analogue of human glucagon-like peptide-1(7-37) carrying two substitutions, alpha-aminoisobutyric acid at position 8 and arginine at position 34, with lysine 26 acylated through a gamma-glutamyl-bis(8-amino-3,6-dioxaoctanoyl) spacer to an octadecanedioic acid chain that confers albumin binding. Its medicinal-chemistry design, GLP-1 receptor affinity and pharmacokinetics in mini-pigs were reported by Novo Nordisk investigators (Lau et al., Journal of Medicinal Chemistry 2015). The human literature is extensive: cardiovascular endpoints were examined in a two-year placebo-controlled trial of 3,297 adults with type 2 diabetes (Marso et al., New England Journal of Medicine 2016), and body-weight endpoints in a 68-week trial of 1,961 adults with overweight or obesity (Wilding et al., New England Journal of Medicine 2021). Semaglutide is the active ingredient of licensed pharmaceutical products in multiple jurisdictions; the research-grade peptide is not a pharmaceutical product.
Research use only. Not for human or veterinary use. This page describes what the compound is and what published literature has examined; it is not guidance on use.
Chemistry
- Class
- GLP-1 / GIP
- CAS number
- 910463-68-2
- Molecular formula
- C187H291N45O59
- Molecular weight
- 4113.6 g/mol (free base)
- Sequence
- H-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(N-epsilon-[2x(8-amino-3,6-dioxaoctanoyl)-gamma-Glu-octadecanedioyl])-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH (31 amino acids; GLP-1(7-37) with Aib8, Arg34, Lys26 acylation)
- Physical form
- Sterile freeze-dried powder
Available as
| Material | Vial | Price | Per mg | Purity | |
|---|---|---|---|---|---|
| Semaglutide 10mgSEMA-10 | 10 mg | $95 | $9.50/mg | ✓ 99.34% | Details → |
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Common questions
What is the CAS number for Semaglutide?
910463-68-2.
What is the molecular formula and weight of Semaglutide?
Semaglutide has molecular formula C187H291N45O59 and a molecular weight 4113.6 g/mol (free base).
What is the sequence of Semaglutide?
H-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(N-epsilon-[2x(8-amino-3,6-dioxaoctanoyl)-gamma-Glu-octadecanedioyl])-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH (31 amino acids; GLP-1(7-37) with Aib8, Arg34, Lys26 acylation).
What strengths of Semaglutide are available?
10 mg, supplied as lyophilised powder. Each carries a measured purity result for the lot in stock.
Is Semaglutide approved for human use?
No. Semaglutide supplied here is a research material for laboratory use only. It is not approved by the FDA or any other regulator for human or veterinary use, and nothing on this page is guidance on use.