Reference · GLP-1 / GIP
AOD-9604
AOD-9604 is a synthetic hexadecapeptide corresponding to residues 177-191 of human growth hormone with an added N-terminal tyrosine, retaining the Cys7-Cys14 disulfide loop of the parent protein. It originated at Monash University, where investigators examined body-weight gain, adipose-tissue lipolytic activity and euglycaemic-clamp insulin-sensitivity endpoints in obese Zucker rats (Ng et al., Hormone Research 2000). Subsequent murine work compared the fragment with full-length hormone for body-weight, energy-expenditure and beta3-adrenoceptor expression endpoints in obese and beta3-AR knock-out mice (Heffernan et al., Endocrinology 2001). Published human data include a summary of safety and tolerability data from six randomised, double-blind, placebo-controlled trials, reporting IGF-1, oral glucose tolerance, anti-peptide antibody and adverse-event endpoints (Stier et al., Journal of Endocrinology and Metabolism 2013). The developer terminated its obesity programme in 2007 after a 24-week Phase IIb trial (Valentino et al., Clinical Pharmacology & Therapeutics 2010), and the compound is not an approved pharmaceutical.
Research use only. Not for human or veterinary use. This page describes what the compound is and what published literature has examined; it is not guidance on use.
Chemistry
- Class
- GLP-1 / GIP
- CAS number
- 221231-10-3
- Molecular formula
- C78H123N23O23S2
- Molecular weight
- 1815.1 g/mol (free peptide, Cys7-Cys14 disulfide-cyclised)
- Sequence
- Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe, Cys7-Cys14 disulfide (16 amino acids)
- Physical form
- Sterile freeze-dried powder
Available as
| Material | Vial | Price | Per mg | Purity | |
|---|---|---|---|---|---|
| AOD-9604 5mgAOD-5 | 5 mg | $68 | $13.60/mg | ✓ 99.28% | Details → |
| AOD-9604 10mgAOD-10 | 10 mg | $110 | $11.00/mg | ✓ 99.21% | Details → |
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Common questions
What is the CAS number for AOD-9604?
221231-10-3.
What is the molecular formula and weight of AOD-9604?
AOD-9604 has molecular formula C78H123N23O23S2 and a molecular weight 1815.1 g/mol (free peptide, Cys7-Cys14 disulfide-cyclised).
What is the sequence of AOD-9604?
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe, Cys7-Cys14 disulfide (16 amino acids).
What strengths of AOD-9604 are available?
5 mg, 10 mg, supplied as lyophilised powder. Each carries a measured purity result for the lot in stock.
Is AOD-9604 approved for human use?
No. AOD-9604 supplied here is a research material for laboratory use only. It is not approved by the FDA or any other regulator for human or veterinary use, and nothing on this page is guidance on use.