Reference · Mitochondrial
SS-31 (Elamipretide)
SS-31, also designated elamipretide, MTP-131 and Bendavia, is a synthetic aromatic-cationic tetrapeptide (D-Arg-2',6'-dimethyltyrosine-Lys-Phe-NH2) from the Szeto-Schiller peptide series, characterised by its localisation to the inner mitochondrial membrane. Investigators have examined its binding to the anionic phospholipid cardiolipin, together with cytochrome c peroxidase activity and mitochondrial respiration endpoints, in isolated mitochondria and rat renal ischaemia models (Birk et al., Journal of the American Society of Nephrology 2013); a review of the series summarises this cell-based and rodent work (Szeto, British Journal of Pharmacology 2014). Human data exist: a randomised placebo-controlled crossover trial with open-label extension (TAZPOWER) examined six-minute walk distance, fatigue scores and knee extensor strength in 12 individuals with Barth syndrome (Reid Thompson et al., Genetics in Medicine 2021). In September 2025 the US FDA granted accelerated approval to an elamipretide hydrochloride pharmaceutical formulation for Barth syndrome; research-grade SS-31 is not that pharmaceutical product.
Research use only. Not for human or veterinary use. This page describes what the compound is and what published literature has examined; it is not guidance on use.
Chemistry
- Class
- Mitochondrial
- CAS number
- 736992-21-5
- Molecular formula
- C32H49N9O5
- Molecular weight
- 639.8 g/mol (free base)
- Sequence
- H-D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2',6'-dimethyl-L-tyrosine; 4 amino acids) - Szeto-Schiller tetrapeptide
- Physical form
- Sterile freeze-dried powder
Available as
| Material | Vial | Price | Per mg | Purity | |
|---|---|---|---|---|---|
| SS-31 (Elamipretide) 10mgSS31-10 | 10 mg | $95 | $9.50/mg | ✓ 99.22% | Details → |
| SS-31 (Elamipretide) 50mgSS31-50 | 50 mg | $125 | $2.50/mg | ✓ 99.77% | Details → |
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Common questions
What is the CAS number for SS-31 (Elamipretide)?
736992-21-5.
What is the molecular formula and weight of SS-31 (Elamipretide)?
SS-31 (Elamipretide) has molecular formula C32H49N9O5 and a molecular weight 639.8 g/mol (free base).
What is the sequence of SS-31 (Elamipretide)?
H-D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2',6'-dimethyl-L-tyrosine; 4 amino acids) - Szeto-Schiller tetrapeptide.
What strengths of SS-31 (Elamipretide) are available?
10 mg, 50 mg, supplied as lyophilised powder. Each carries a measured purity result for the lot in stock.
Is SS-31 (Elamipretide) approved for human use?
No. SS-31 (Elamipretide) supplied here is a research material for laboratory use only. It is not approved by the FDA or any other regulator for human or veterinary use, and nothing on this page is guidance on use.